Veröffentlichungen

2026

Nat Commun [accepted manuscript]. 10. March 2026.
Generation of marmoset monkeys with a non-mosaic disruption of the OTOF gene as a model of human deafness
Kahland T, Lindenwald DL, Jeschke M, Kusch K, Tkachenko Eikel O, Uhl M, Rüger N, Drummer C, Wolf B, Benseler F, Brose N, Behr R, Moser T

bioRxiv [Preprint]. 09. March 2026. doi: 10.64898/2026.03.06.710066
Image modifications reduce differences in natural-image encoding by retinal ganglion cells between natural and optogenetic stimulation
Ramakrishna V, Gollisch T

bioRxiv [Preprint]. 09. March 2026. doi: 10.64898/2026.03.06.710089
Arousal elicits a brain-wide hemodynamic wave independent of locus coeruleus noradrenergic tone
Martinez de Paz JM, Mayer JL, Wanken P, Rodrigues Apgaua B, Ablitip A, Behera L, Macé E

bioRxiv [Preprint]. 06. March 2026. doi: 10.64898/2026.03.06.709845
A transition-prone brain state precedes spontaneous behavioral switching
Wanken P, Edelman BJ, Behera L, Martinez de Paz JM, McCarthy PT, Macé E

BioRxiv [Preprint]. 02. March 2026. doi: 10.64898/2026.03.02.709025
Nanobodies equipped with HaloTag variants enable rapid and straightforward one-step immunofluorescence lifetime multiplexing
Albert L, Basak S, Koerner H, Oleksiievets N, Mougios N, Cotroneo ER, Frei MS, Enderlein J, Broichhagen J, Simeth NA, Tsukanov R, Opazo F

MedComm. 02. March 2026. doi: 10.1002/mco2.70639
OTOF Gene Therapy: From Breakthroughs to Roadmaps
Wang Q, Moser T, Petit C

Sci Adv. 20. February 2026. doi: 10.1126/sciadv.adz3026
Structures of the 26S proteasome in complex with the Hsp70 co-chaperone Bag1 reveal a mechanism for direct substrate transfer
Maestro-López M, Cheng TC, Muntaner J, Menéndez M, Alonso M, Schweitzer A, Ishizaka M, Tomko RJ Jr, Cuéllar J, Valpuesta JM, Sakata E

bioRxiv [Preprint]. 08. February 2026. doi: 10.64898/2026.02.05.703927
Microtubule Stabilization and Biomaterial Guidance Synergize to Enhance CST Regeneration and Motor Recovery After Chronic SCI
Nekanti U, Sakthivel PS, Nishi RA, Anzalone A, Dumont CM, Lee JB, McDonald S, Song H, Obenaus A, Gershon PD, Bradke F, Shea LD, Cummings BJ, Anderson AJ

MedRxiv [Preprint]. 04. February 2026. doi: 10.64898/2026.01.28.26344748
XPOT Deficiency causes a human disorder through impaired tRNA nuclear export
von Hardenberg S, Niehaus I, Wiemers A, Rothoeft T, Huang K, Petree C, Schäffer V, Phillipe C, Bruel AL, Warnatz K, Zamani M, Ahmadi R, Sedaghat A, Bahram S, Sedighzadeh S, Ebrahimi S, Khalilian S, Landwehr-Kenzel S, Schwerk N, Elsayed A, Rösler J, Lin SJ, Sabu S, Strenzke N, Sogkas G, Vona B, Varshney GK, Di Donato N, Auber B

PsyArXiv [Preprint]. 16. January 2026. doi: 10.31234/osf.io/dpcwy_v2
Burst-related potentials as a temporal anchor for cognition
Schuma MC, Landau AN, Diester I, Anderson MC, Karvat G

Mol Neurobiol. 10. January 2026. doi: 10.1007/s12035-025-05615-9
Expansion of Molecular and Clinical Aspects of EPS8L2 (DFNB106)-Associated Hearing Loss Emphasizes a Potential Therapeutic Window
Owrang D, Rad A, Alerasool M, Kolb SM, Lin SJ, Doll J, Alidadiani N, Ghaderi S, Hofrichter MAH, Maroofian R, Varshney GK, Mojarrad M, Bartsch O, Haaf T, Vona B

2025

BioRxiv [Preprint]. 18. December 2025. doi: 10.64898/2025.12.18.694605
Slowdown of microtubule retrograde flow enables axon and dendrite development and maintenance
Schelski M, Pietralla T, Günter C, Stern S, Pavin N, Bradke F

BioRxiv [Preprint]. 14. December 2025. doi: 10.1101/2024.02.15.580451
Cortical population coding critically depends on fine-tuning of cell physiology
Revah O, Wolf F, Gutnick MJ, Neef A

EMBO Mol Med. 09. December 2025. doi: 10.1038/s44321-025-00350-z
Channelrhodopsin variants for high-rate optogenetic neurostimulation at low light intensities
Roos L, Garrido-Charles A, Albrecht N, Vavakou A, Alekseev A, Bleyer M, Thirumalai A, Mittring A, Alvanos T, Huet AT, Bamberg E, Kusch K, Wolf BJ, Moser T, Mager T

MedRxiv [Preprint]. 27. November 2025. doi: 10.1101/2025.11.25.25339647
A Comparative Survey of Functional Evidence Use in Hearing and Vision Loss Genetics
Inan RA, DiStefano MT, Amr SS, Beißbarth T, Starita LM, Stergachis AB, Tayoun AA, Hufnagel RB, Vona B

BioRxiv [Preprint]. 17. November 2025. doi: 10.1101/2025.11.16.688700
CochleaNet: deep learning-based image analysis for cochlear connectomics and gene therapy
Roos L, Miraç Diniz A, Koert E, Schilling M, Uhl M, Thirumalai A, Aakhte M, Kusch K, Huisken J, Moser T, Pape C

Curr Neurol Neurosci Rep. 05. November 2025. doi: 10.1007/s11910-025-01466-y
Neurogenetic Disorders with Hearing Loss: Mechanisms, Classifications, and Emerging Insights
Owrang D, Vona B

Sci Adv. 17. October 2025. doi: 10.1126/sciadv.ady8532
Structure and function of otoferlin, a synaptic protein of sensory hair cells essential for hearing
Chen H, Cretu C, Trebilcock A, Evdokimova N, Babai N, Feldmann L, Leidner F, Benseler F, Mutschall S, Esch K, Szabo CZK, Pena V, Pape C, Grubmüller H, Strenzke N, Brose N, Wichmann C, Preobraschenski J, Moser T

QJM. 15. October 2025. doi: 10.1093/qjmed/hcaf246
Uncovering Dual Molecular Diagnoses in Families with Complex Phenotypes through Structural and Clinical Study of Novel COL4A6 Variants
Owrang D, Rad A, Cretu C, Lin SJ, Mustafa HM, Huang K, Waheed N, Hussain M, Riaz S, Preobraschenski J, Varshney GK, Oprea G, Vona B

Brain Commun. 06. October 2025. doi: 10.1093/braincomms/fcaf385
Targeted environmental enrichment is more effective than bipedal treadmill training after thoracic spinal cord injury
Griffin JM, Bockemühl T, Randel B, Gröschl S, Papaioannou P, Büschges A, Bradke F

Med. 01. October 2025. doi: 10.1016/j.medj.2025.100886
International expert consensus on gene therapy for hereditary hearing loss: Based on clinical trials
Fan X, Gao Z, Zhong J, Chen Y, Chen X, Landegger LD, Moser T, Zeng FG, Sun Y, Jin X, Nash R, Chien WW, Jiang D, Greinwald JH, Bance M, Rodríguez MM, Lee SY, Feng G, Yang H, Wu CC, Xu L, Yuan W, Feng Y, Zhao Y, Vona B, Strenzke N, Beutner D, Amin N, Arwyn-Jones J, Chandrasekeharan D, Shi D, Zhang D, Yang J, Qi J, Wang Q, Yin Y, Cheng YF, Tao Y, Yu Y, Wang D, Jiang L, Guo L, Chen L, Cheng X, Cui C, Lv J, Han S, Wang W, Li Y, Gao X, Liu XZ, Zha D, Shi H, Chen B, Wang Q, Yuan H, Yang S, Yin S, Wu H, Wang Z, Li H, Rubinstein JT, Lustig LR, Chai R, Chen ZY, Shu Y

MedComm. 08. September 2025. doi: 10.1002/mco2.70363
Is CABP2-Associated Hearing Loss (DFNB93) a Gene Therapy Target? Preclinical Progress and Patient Registry
Vona B, Wollnik B, Strenzke N, Pangršič T, Moser T

Mol Biol Cell. 28. August 2025. doi: 10.1091/mbc.E24-11-0519
SynapseNet: Deep Learning for Automatic Synapse Reconstruction
Muth S, Moschref F, Freckmann L, Mutschall S, Hojas-Garcia-Plaza I, Bahr JN, Petrovic A, Do TT, Schwarze V, Archit A, Weyand K, Michanski S, Maus L, Imig C, Hintze A, Brose N, Wichmann C, Fernandez-Busnadiego R, Moser T, Rizzoli SO, Cooper BH, Pape C

medRxiv [Preprint]. 25. August 2025. doi: 10.1101/2025.08.13.25333146
The TECTB-C225Y Variant Causing Autosomal Dominant Deafness in a Nicaraguan Family Enhances Sensitivity to Noise-Induced Hearing Loss in Mice
Hale EB, Vona B, Goodyear RJ, Osgood RT, Amr SS, Mojica K, Vera-Monroy R, Callahan K, Gudlewski KL, Quadros R, Ohtsuka M, McGee J, Walsh EJ, Morton CC, Gurumurthy C, Saunders JE, Richardson GP, Indzhykulian AA

J Neural Eng. 01. August 2025. doi: 10.1088/1741-2552/adf00f
Hearing restoration by a low-weight power-efficient multichannel optogenetic cochlear implant system
Jablonski L, Harczos T, Wolf B, Hoch G, Khurana L, Dieter A, Roos L, Hessler R, Ayub S, Ruther P, Moser T

Mol Diagn Ther. 01. July 2025. doi: 10.1007/s40291-025-00782-w
Recurrent and Novel Pathogenic Variants in Genes Involved with Hearing Loss in the Pakistani Population
Shadab M, Ben-Mahmoud A, Martínez Völter LN, Abbasi AA, Ku B, Ejaz A, Latif Z, Gupta V, Owrang D, Jang MH, Zhang Z, Mohammad R, Houlden H, Kim HG, Vona B

medRxiv [Preprint]. 28. June 2025. doi: 10.1101/2025.06.26.25330137
Domain specific phenotypic expansion associated with variants in MACF1
Gogate N, Jolly A, Rosenfeld JA, Bahena-Carbajal P, Bernstein JA, Bonner D, Busa T, Cristian I, D'Souza P, Friedman J, Gorokhova S, Haaf T, Herman I, Isin UU, Jhangiani SN, Johnson I, Lenberg J, Macnamara EF, Maroofian R; Undiagnosed Diseases Network, Melissa Racobaldo; Redlich OL, Tifft C, Tos T, Vona B, Zambrano RM, Wentzensen IM, Wigby K, Pehlivan D, Gibbs RA, Lupski JR, Posey JE

STAR Protoc. 18. June 2025. doi: 10.1016/j.xpro.2025.103908
Protocol for a minigene splice assay using the pET01 vector
Andreae H, Curcio M, Owrang D, Esmaeelpour S, Jahnke F, Benseler F, Brose N, Vona B

Nat Commun. 09. April 2025. doi: 10.1038/s41467-025-58738-x
Visual target and task-critical feedback uncertainty impair different stages of reach planning in motor cortex
Amann LK, Casasnovas V, Gail A